Botulinum toxin 100 iu – 10 Vials

Botulinum Toxin (commonly referring to Botulinum Neurotoxin Type A, BoNT/A) is a potent neurotoxic protein research compound derived from Clostridium botulinum. It consists of a 150 kDa dichain molecule with a heavy chain (~100 kDa) responsible for neurospecific binding and translocation, and a light chain (~50 kDa) that functions as a zinc-dependent metalloprotease. In preclinical models, Botulinum toxin binds to presynaptic cholinergic nerve terminals (via receptors such as SV2 and polysialogangliosides), undergoes endocytosis, and translocates its light chain into the cytosol, where it specifically cleaves SNAP-25 (a key component of the SNARE complex). This proteolytic cleavage inhibits SNARE-mediated synaptic vesicle fusion, preventing acetylcholine release at neuromuscular junctions and leading to temporary flaccid paralysis, muscle relaxation, and reduced neurotransmission. Botulinum toxin is utilized in research to investigate mechanisms of neurotransmitter release, synaptic vesicle exocytosis, neuromuscular junction physiology, pain pathways (including inhibition of neuropeptides like substance P and CGRP), and therapeutic strategies for conditions involving muscle hyperactivity, spasticity, dystonia, chronic pain, and neurodegenerative processes, as well as broader roles of SNARE proteins in cellular trafficking and neuronal signaling